| Research
Information: |
| |
To
assess the detoxification efficacy, these medicines
were subjected to animal trials and thoroughly
tested upon animals of various species for different
intoxicants such as :
|
| Alcohol:
At first, these medicines
were tested for addiction of alcohol in
monkeys. To begin with, experimental neurosis
was developed in monkeys by subjecting them
to neurotogenic trauma.They were served
food; and a rubber snake was concealed in
their food. While eating, they sighted the
rubber snake in their food.They got agitated
and refused to eat. By virtue of repetition
of this process, neurosis developed in them.
Then, they were given 1.5 ml/kg (body weight)
alcohol. This dose of alcohol disintegrated
the neurotic complex. Neurotic monkeys,
when mildly intoxicated, resumed eating.
After experiencing relief from neurotic
tension, they preferred taking some alcohol
before meals; otherwise, they were unable
to take food. Hence, addiction to alcohol
developed in them.
These
monkeys were divided into two groups. One
group was given Detoxin and the
other group was given Placebo with following
results:
| Group
treated with |
No.
of monkeys treated |
No.
of monkeys resumed eating without
alcohol |
No.
of monkeys resumed eating but less
without alcohol |
No.
of monkeys did not resume
eating |
| Detoxin |
10 |
8 |
1 |
1 |
| Placebo |
10 |
Nil |
1 |
9 |
 Top |
|
| Morphine:
Acute dependence
This experiment was conducted upon Albino
mice. Samples of 60 Albino mice were taken
and were given Morphine HCL 20 mg/kg (body
weight). About 4 hours later these mice
were divided into two groups. One group
was given Detoxin and the other one
Placebo. After 5 minutes. both groups were
given Nalaxone 5 mg/kg (body weight). Following
results observed:
| Group
treated with |
Total
no. of mice |
no
withdrawals found in |
Rearing
occurred |
Jumping,
urination, defaecation occurred in |
| Detoxin |
30 |
22 |
7
|
1
|
| Placebo |
30 |
3 |
27 |
27
|
|
|
| |
| Barbiturates
For this experiment, samples of 20 cats
were taken. They were given Sodium Barbital
95 mg/kg (body weight) two times daily and
this dose was increased gradually, until
the dose level of Sodium Barbital reached
to 200 mg/kg in 180 days. Then, these cats
were divided into two groups and were deprived
of Sodium Barbital. Thereafter, one group
was given Detoxin and Placebo was
given to the other group. Following
results observed:
| Group
treated with |
No.
of cats |
Strong
seizures occurred in |
Mild
seizures occurred in |
seizure occurred in |
| Detoxin |
10 |
- |
2
|
8
|
| Placebo |
10 |
9 |
1 |
-
|
|
|
 Top |
| Clinical
Trial
192
cases of addicts of various types were studied.
Directly administering Detoxin to
the control group was not considered necessary
as Placebo effect gets nullified while testing
the potencies. Moreover, each potency of
Detoxin can not suit to a person.
Had there been placebo effects, each potency
of Detoxin would suit. This study
of 192 cases was conducted for 1 year. The
Observations are as follows:
AGE
:
| Below
20 yrs. |
21-30
yrs. |
31-40
yrs. |
41-50
yrs. |
51-60
yrs. |
Above
60 yrs. |
| 14 |
72 |
57 |
25 |
17 |
7
|
Educational
Status :
| Nil |
Primary
School |
Junior
High School |
High
School |
Intermediate |
| 39 |
17 |
25 |
32 |
29 |
| Graduate |
Post
Graduate |
Professionals |
Misc. |
| 23 |
9 |
13 |
5 |
Profession
:
| Unemployed |
Govt.
Service |
Advocate |
Farmer |
Driver |
Hotel |
Business |
| 26 |
18 |
4 |
34 |
16 |
2 |
21 |
| Pvt.
Service |
Transfer interrupted!
-serif">Doctor |
Student |
Technical |
Laborer |
Misc. |
| 9 |
5 |
15 |
4 |
4 |
34 |
Top
Marital Status :
| Unmarried |
Married |
Widower |
Divorcee |
Separated |
| 22 |
91 |
10 |
27 |
42 |
Addiction
:
| Alcohol |
Cannabis |
Opiates |
Alcohol,
Cannabis |
Alcohol,
Opiates |
| 69 |
13 |
58 |
15 |
9 |
| Alcohol,
Diazepam, Opiates |
Alcohol,
Cannabis, Opiates |
Opiates,
Diazepam |
Cannabis,
Opiates |
| 3 |
9 |
1 |
15 |
Relapse
:
| Alcohol |
Cannabis
|
Opiates |
Alcohol,
Cannabis |
Alcohol,
Opiates |
| 32 |
4 |
26 |
3 |
3 |
| Alcohol,
Diazepam, Opiates |
Alcohol,
Cannabis, Opiates |
Opiates,
Diazepam |
Cannabis,
Opiates |
| 1 |
2 |
1 |
6 |
Top
Relapsed During :
| 0-3
months |
3-6
months |
6-9
months |
After
9 months |
| 35 |
21 |
12 |
10 |
Relapsed
Due to :
| Withdrawal |
Craving |
Impotency |
Family
Tension |
Company |
Drug
Peddling |
| 3 |
4 |
31 |
14 |
9 |
17 |
Another
separate study was also conducted in which
cases of smoking/chewing tobacco were
studied; though, some of them used to
take occasionally other intoxicants or
were addicted to them such as alcohol,
cannabis, sedatives, Hypnotics and antidepressent.
Details are as follows :
Addiction
:
| Chewing
Tobacco |
Smoking |
Both |
| 95 |
531 |
41 |
Relapse
:
| Chewing
Tobacco |
Smoking |
Both |
| 19 |
117 |
8 |
Top
Relapsed During :
| 1st
week |
2-4
week |
2-3
months |
3-6
months |
6-9
months |
After
9 months |
| 23 |
36 |
21 |
26 |
23 |
15 |
Relapsed
Due to :
| Did
not take medicine properly |
Urge |
With-drawl |
Persuasion
by someone |
curiosity |
| 19 |
13 |
5 |
8 |
32 |
| Mental
shock |
no
reason |
Loneliness |
Desire
to hold some- thing between fingers |
ignorance of the medical instructions |
| 12 |
27 |
4 |
6 |
18 |
When
they smoked again, they experienced :
| Aversion |
Usual
taste |
Mild
taste /tastelessness |
| 63 |
37 |
44 |
The
persons who got relapsed, started to take
quantity/day :
| Reduced
|
Same
|
increased |
| 88 |
43 |
13 |
|
|
| Top |
| |
| |
|
|
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